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Erectile dysfunction (ED) – the inability to achieve and/or maintain an erection sufficient for sexual intercourse – remains an important social and medical problem worldwide. According to modern concepts, sexual stimulation activates the parasympathetic nervous system. Release of mediators, in particular nitric oxide (NO, endothelial relaxing factor), from endothelium of vessels of cavernous bodies leads to accumulation of cyclic guanosine monophosphate (cGMP) in cavernous tissue and relaxation of smooth muscle cells of walls of bringing arteries and cavernous bodies. Filling of cavernous bodies with arterial blood causes compression of venules and blocking of blood outflow from the penis – an erection occurs.
Vascular smooth muscle cells metabolize cGMP with phosphodiesterase type 5 (FDE5). Relaxation causes the smooth muscle cells to shrink, decreasing blood flow through the arteries and increasing venous outflow. ED can be due to insufficient vasodilation due to cGMP deficiency or decreased vascular sensitivity to cGMP, lack of penile vein compression due to connective tissue overgrowth, or a combination of these causes. It is believed that ED in 80% of cases occurs due to various organic causes and in 20% due to psychological factors. Often there is a combination of these factors. Causes of ED include age, smoking, diabetes, atherosclerosis and others. Drug therapy, such as thiazide-type diuretics, non-selective beta-adrenoblockers, sympatholytics, etc., can contribute to the occurrence of ED.
For many centuries, in order to prolong sexual longevity, various stimulating agents were used, mainly of plant origin, many of which belonged to excitatory agents and had hallucinogenic, psychostimulant and other properties. For example, for many centuries, in Oriental medicine, the seahorse has been used to enhance sexual function and to overcome sexual weakness, eliminate frigidity in women, premature ejaculation in men, increase the completeness and brightness of orgasmic sensations. Hirohoto (1901-1989), the penultimate Japanese emperor, who was interested in marine biology and left a number of interesting works in this field, has made a definite contribution to the study of the biological properties of the seahorse.
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